In fact, in the games the whole world reshaping thing was just a delusion of one person, right before Wesker killed him. Adaptational Villainy: Umbrella as whole gets this treatment with the reveal that they knowingly started a T-virus pandemic in order to reshape the world in their image, something they would never go for in the original games.Isaacs' plan to militarize their research and whose primary plot importance is being Alicia Marcus/Alice's father. However, whereas in the games he was a Mad Scientist and the Big Bad of Resident Evil 0, here he's a fairly idealistic figure who was opposed to Dr. Adaptational Heroism: Like the games, The Final Chapter reveals one of the co-founders of the Umbrella Corporation was James Marcus, who was killed by his business partner about a decade before the Raccoon City Incident in a move to seize control of the company.Isaacs was in cryostasis, so the Isaacs that died in Extinction and the one pursuing Alice in this film were mere clones.

You'd be hard-pressed to do that with an axe under ideal conditions. Absurdly Sharp Blade: Alice chops off the clone Isaacs' left hand with a combat knife in a single clean cut while clinging to the side of a tank.Resident Evil: The Final Chapter provides examples of:

Movie resident evil final chapter